In addition to a huge array of heritage listings and landmarks, residents of Brisbane CBD enjoy access to major Brisbane landmarks and attractions such as City Hall (which incorporates the Museum of Brisbane), the Story Bridge, the Howard Smith Wharves redevelopment, Anzac Square, St Johns Cathedral, The Brisbane River and Riverwalk network, the City Botanic Gardens, Roma Street Parkland, Queensland Parliament House and Old Government House, Customs House, Eagle Street Pier, Queen Street mall as well as countless options for commercial and retail needs, world-class shopping, bars, cafes and dining. Brisbane CBD residents have access to a number of highly sought-after schools serviced by neighbouring suburbs including Petrie Terrace State School, The Albert Park Flexi School, Brisbane Girls Grammar, Brisbane Grammar School and Brisbane Central State School.

Acting as the prime central business district for Queensland, residents of Brisbane CBD are spoilt for choice when it comes to transport and access in and out of the suburb. The CBD is serviced by four road bridges that connect the CBD to the southern suburbs, Captain Cook Bridge, Victoria Bridge, William Jolly Bridge and the Go Between Bridge whilst the Story Bridge connects neighbouring Fortitude Valley to Kangaroo Point. Access to the Pacific Motorway is via Captain Cook Bridge whilst the Riverside Expressway, Inner-city Bypass, Clem Jones Tunnel and Airport Link all provide links to Western, Northern, Southern and Eastern suburbs. Residents of the CBD can also enjoy access to a variety of bicycle, foot and ride-sharing options in addition to a huge number of high frequency bus routes, high-speed City Cat ferry services and high frequency, full-service train routes running out of Roma Street Station, Central Station and nearby Fortitude Valley Station.